Transplantation of NGF-Gene-Modified Bone Marrow Stromal Cells into a Rat Model of Alzheimer’ Disease
نویسندگان
چکیده
منابع مشابه
The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer’s disease
Objective(s): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. Materials and Methods: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat mod...
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Background & Objective: Bone marrow stromal cells (BMSCs) are multipotent stem cells that can proliferate and differentiate into osteogenic cells . T his study aimed to investigate the effects of BMSC transplantation for the repair of bone defects in the rat. Materials & Methods : Twenty-eight male adult rats were divided into 4 groups. Group 1 ( control group) received no treatment after the...
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Background: Bone marrow stromal cells (BMSC) are used as a source for cell therapy in different model for neurological disorder such as stroke and spinal cord injury. However, the transdifferentiation of BMSC into cholinergic phenotype requires more investigation. Methods: BMSC were isolated from adult rats, pre-induced with β-mercaptoethanol (BME) and followed by nerve growth factor (NGF) indu...
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Background: Bone marrow stromal cells (BMSC) have been successfully employed for movement deficit recovery in spinal cord injury (SCI) rat models. One of the unsettled problems in cell transplantation is the relative high proportion of cell death, specifically after neural differentiation. According to our previous studies, p75 receptor, known as the death receptor, is only expressed in BMSC in...
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Purpose: The assessment of the ability of combined treatment of bone marrow stromal cells graft (BMSCs) and oral administration of Coenzyme (CoQ10) in rat model of Parkinson disease as a good substitute for common current Parkinson treatments, and the comparison of this combined treatment method with alone application of these treatments. Materials and Methods: In this experimental study of mal...
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ژورنال
عنوان ژورنال: Journal of Molecular Neuroscience
سال: 2008
ISSN: 0895-8696,1559-1166
DOI: 10.1007/s12031-008-9043-0